In response to DNA damage from environmental or endogenous sources, cells evoke an elaborate signaling network known as the DNA damage response (DDR). This response functions to preserve genomic integrity, which is necessary for the prevention of cancer. We study the DNA damage response, focusing on pathways regulated by ubiquitin-dependent signaling and involving replication-coupled repair. Our ultimate goal is to understand how DDR disruption influences cancer progression and can be exploited to target tumors with specific DNA repair defects. The laboratory is part of the Center for Cancer Research (CCR) and Department of Radiation Oncology at Massachusetts General Hospital.